Tag Archives: autonomic

New book cover, and ebook price is cut to $6.99!

Hi Rez Cover ebook gut brain

I’ve been working on rewriting my book description, as I’ve never liked the one I used. So, today’s post is all about updates on TSF. I’m working on the next book too, and it’s all about applying the information from TSF to everyday life! So, here’s the update so far, with a linky at the bottom:

What if many of the things you thought you knew about being human did not actually work the way you were taught?

What if scientific research into gut bacteria had revealed huge amounts of information about their role in human function, health, emotions and appetite and healthcare hadn’t caught up at all?

What if you could find out the key to controlling your weight without starving yourself or undergoing dangerous surgery?

What if the book you’re looking at could teach you about the explosion of scientific research on the microbiome, without you having to read a few thousand studies to understand it?

You’ve probably heard that our gut bacteria vastly outnumber our human cells, and our gut bacteria’s gene pool includes more than one hundred times the gene count as our human cells. What does that mean and how does it work?

If you’re interested in knowing more about “what makes us tick” physically and emotionally, how to hurt less and age more gracefully, then this book is for you!

If you’re tired of books that state the author’s opinion or make broad claims without scientific backing or support, this book includes about 1300 peer-reviewed research studies, and the e-book has links to those studies on the National Library of Health/National Library of Medicine.

One of the inspirations for this book was research published by the late Prof. Eshel Ben-Jacob, a brilliant Israeli researcher. I was able to share this book with him before he passed away, and this is what he said about it:

“This excellent and long needed book presents in a clear and sound manner the recent dramatic findings about our gut bacteria. These thousands of trillions microorganisms living inside us play a crucial role in regulating our well-being throughout life. The new message is of great importance to the entire medical community, life sciences researchers, as well as the general public. Realizing the role of gut bacteria can help each of us to better understand the effect of nutrients, as mediated by the gut bacteria, on our body in health, in disease and in special times, such as pregnancy, nursing or periods of high stress. For example, we now understand that the massive use of antibiotics in children, adults and agriculture has endangered our vital microbiome and is liable to cause diseases such as Type 2 diabetes on a global scale. The gut microbiome is emerging as a vital part of humanity, without which health and happiness are severely compromised. The time has come for this knowledge to be widely understood!”

Professor Eshel Ben-Jacob, International member of the American Philosophical Society

Professor of Physics
The Maguy-Glass Professor
in Physics of Complex Systems
School of Physics and Astronomy
Tel Aviv University, 69978 Tel Aviv, Israel

http://www.amazon.com/Symbiont-Factor-Bacteria-Microbiome-Redefines-ebook/dp/B00LV6H1UY/ref=tmm_kin_swatch_0?_encoding=UTF8&qid=1443640302&sr=8-6

Mood: Does it affect gut symbiont health and intestinal function?

flow chart stress intestinal function inflammation

What are the causes of dysbiosis and resultant dysfunction/disease? One cause that seems to be greatly underestimated may be simply our mood! Human beings, having been gifted with large frontal lobes, are capable of experiencing and expressing a variety of moods. Our bodies respond to these moods with different functional states, some of which have been categorized. These are “fight or flight (or sometimes, fight/flee/fortify)” or “wine and dine”.  There are many more physiological functional arousal states that we could elaborate on, but many of them could make this blog post NSFW. We’ll just assume that your imagination can fill in the blanks with how the body responds to the mind! With the brain-gut connection in mind, and being also cognizant that it’s a two-way street since the gut influences the brain, what would be the influence of stress? One that comes to mind right away is a reduction in gut motility. This changes the environment in which the microbiome exists, and will change the demographics of the microorganisms. What about the effects of peristalsis on the small intestine? If there is less peristalsis, wouldn’t it make it easier for colonic organisms to migrate to the small intestine? If transit times increase, different stages of food digestion could release different nutrients, feeding different organisms. When do we cross from fermentative to putrefactive dominance? Using one of the concepts in The Symbiont Factor, this two-way function of gut/brain/gut axis can cause a positive feedback loop. If gut organisms that flourish during emotional stress can also alter neurotransmitter function at the brain, wouldn’t that predispose the brain to perceive stress following stressful events? What if that is why sometimes after a stressful day we just have more stress, no matter what happens? It is as if our very perception of our environment is vulnerable to plasticity. If this is allowed to happen without our conscious intervention (things like deciding to meditate or do some yoga even though you’re angry) the combination of evoked brain plasticity with gut symbiont evolution could be what makes it hard to shake off stress! Ironically, this same plasticity is probably an evolutionary advantage, allowing genetic selection of the microbiome on an ongoing real-time basis to adapt to circumstances. The problem is that our modern circumstances provide constant chemical and emotional pressure to this system, resulting in “learned dysfunction” of both the gut and the brain!  This highlights the importance of “mental housekeeping” and lifestyle choices in determining our “perceptual future”. If you don’t want the world to seem as stressful, start taking care of mind, body, and symbiont health!

The Problem with RoundUp and its health effects

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The Problem with RoundUp and its health effects
Sometimes during a debate it becomes obvious that one side is simply not telling the truth. Such seems to be the case when considering RoundUp, currently still promoted as the safest herbicide ever produced. It is also the most commonly used, with a recorded 187 million pounds used by US farmers in 2007. More current usage is not known, but estimated at over 200 million pounds in the US. The maker of RoundUp, Monsanto, continues to maintain that it is nontoxic and completely safe. This belief permeates to those who use it, with readers offering comments at the end of the article defending its safety. Most homeowners use RoundUp to control weeds, and most farmers use it liberally on crops. This is possible because of genetic modification of crops to permit resistance to glyphosate, permitting the killing of weeds without killing the crop. Recently articles have been published online suggesting that the problem with wheat causing celiac disease or gluten sensitivity has more to do with residual levels of glyphosate than with gluten content. The suggestion that pre-harvest spraying of crops with glyphosate to reduce weed content, promote dessication and improve yield is typically met with a hailstorm of accusations of “pseudoscience” and “fearmongering.” There are usually some vehement denials that pre-harvest spraying is ever carried out. An example of one such article can be found here: http://tinyurl.com/n9rtzpn

With this in mind let us consider two questions: Is glyphosate toxic, and are crops really sprayed prior to harvest?

The reason that glyphosate is “considered safe” is that it inhibits a metabolic pathway in plants known as the Shikimate pathway. This inhibition interrupts the plant’s metabolism and kills it. Humans and other eukaryotic species do not have a Shikimate pathway, and so the claim of safety appears to be scientifically sound…or is it? All eukaryotic organisms including humans have cellular power-producing structures known as mitochondria. These structures are where energy is produced so that the cell and the organism have fuel. Mitochondria, however, are really not of human origin. Thought to be the end result of ancient indwelling symbionts (endosymbiont theory if you’d like to look that up) mitochondria are more similar to bacteria than human cells. Their DNA is circular, just as bacterial DNA is circular. This isn’t some new discovery as geneticists have been using this mitochondrial DNA to track the human family tree for years. You see, mitochondrial DNA is matrilineal-it is only inherited from the mother, not from the father. This provides a unique opportunity to track one side of the family tree more accurately than is possible with human DNA. It’s also the first clue to glyphosate’s toxicity, as bacteria have a Shikimate pathway! Predictably mitochondria also have a Shikimate pathway. There is already a research paper stating this (Mesnage, Seneff). There is also an effect in the microbiome, as glyphosate is more toxic to some microorganisms than to others, causing an imbalance in this critical ecosystem. Kruger found that glyphosate reduced the inhibition of Clostridium (a pathogen) by Enterococcus species, causing imbalance and disease. A differential toxic effect was found in chickens by Shehata, who showed the glyphosate inibited beneficial microbial species yet did not inhibit pathogenic ones. Changes in gut bacteria in humans can alter serotonin levels, affecting behavior, mood and susceptibility to brain trauma (Morley). The microbiome living in our intestines are critical to our health and are vulnerable to changes in intestinal function (Matthews). It has been found that at very dilute concentrations, far less than commercial farming uses, glyphosate reduces intestinal motility (Chlopecka). This would result in more constipation, dramatic shifts in population dynamics and an increased risk of small intestinal bacterial overgrowth (SIBO) due to reduced motility allowing contents of the colon to move into the small intestine. Glyphosate has been found to trigger pathways producing cellular apoptosis (think cell sepuku) and increased reactive oxygen species producing damaging oxidation (Chaufan).
There is always someone who, in the comments following an article critical of Roundup, offers to drink a glass of it to prove its safety. This is ill advised, as glyphosate is far from nontoxic. Instead, it has been found to produce respiratory depression, bradycardia (so, you can’t breathe and your heart slows), acidosis, hyperkalemia, cardiac block or arrythmia and death. Hemodialysis and intubation are required to help the patient survive, as there is no antidote to glyphosate poisoning (Garlich, Gress).

Okay, so Roundup is definitely toxic in many ways even at small doses. What about all of the people who argue that it is not recommended for use before harvest? Doing a basic search on the internet looking for pre-harvest advice as a farmer provides some insight into this! Monsanto itself provides a “Pre-Harvest Staging Guide” for using RoundUp: http://tinyurl.com/q2o8f96. North Dakota State University published “Glyphosate as a Pre-Harvest Aid in Small Grains” July 2014: http://tinyurl.com/ll98tfj. Michigan State University published something similar for soybeans: http://tinyurl.com/o6f5dqy. University of Arizona Extension also got in on the game, publishing a guide to pre-harvest spraying of wheat to kill broad-leaf weeds: http://tinyurl.com/ljs6547. Similar publishing can be found at http://tinyurl.com/l69bdzc, http://tinyurl.com/kbem9ht, http://tinyurl.com/k6o4lwf, and http://tinyurl.com/m7nxm6a.

You might notice that many of these organizations providing pre-harvest spraying guidelines are university agricultural programs. If you’re not familiar with ag programs, you might even wonder why they would recommend such a practice in light of the research information on glyphosate’s biologic effects (and there are many more articles showing its effects; I didn’t even scratch the surface really!). The old adage of “follow the money” could never be more accurate: http://tinyurl.com/mhyvwzy, http://tinyurl.com/ctw2aq7 as the codependent relationship that has evolved between Monsanto and institutes of higher education is both diabolically brilliant and nauseatingly common.

If you needed more reasons to shop for organically grown fruits and vegetables or use grains other than wheat, you now have them. If you think just avoiding wheat will solve the problem, consider that the same recommendations exist for barley, oats, flax, canola, peas, lentils, soybeans and dried beans (page 31 of http://tinyurl.com/q2o8f96 lists all of these as recommendations for pre-harvest spraying in Canada, and others list ‘small grains’ in the guidelines: http://tinyurl.com/o994mk2).

We have arrived at a time in history when the business interests of corporate entities often take precedence over the health needs of society’s human members. When we allow large corporations to control what is taught in schools and what guidelines are imposed by government, we can count on one thing-being counted out of the deal.

References quoted:
1: Shaw CA, Seneff S, Kette SD, Tomljenovic L, Oller JW Jr, Davidson RM.
Aluminum-induced entropy in biological systems: implications for neurological
disease. J Toxicol. 2014;2014:491316. doi: 10.1155/2014/491316. Epub 2014 Oct 2.
Review. PubMed PMID: 25349607; PubMed Central PMCID: PMC4202242.
2: Gress S, Lemoine S, Séralini GE, Puddu PE. Glyphosate-Based Herbicides
Potently Affect Cardiovascular System in Mammals: Review of the Literature.
Cardiovasc Toxicol. 2014 Sep 23. [Epub ahead of print] PubMed PMID: 25245870.
3: Chłopecka M, Mendel M, Dziekan N, Karlik W. Glyphosate affects the spontaneous
motoric activity of intestine at very low doses – in vitro study. Pestic Biochem
Physiol. 2014 Jul;113:25-30. doi: 10.1016/j.pestbp.2014.06.005. Epub 2014 Jun 24.
PubMed PMID: 25052523.
4: Morley WA, Seneff S. Diminished brain resilience syndrome: A modern day
neurological pathology of increased susceptibility to mild brain trauma,
concussion, and downstream neurodegeneration. Surg Neurol Int. 2014 Jun 18;5:97.
doi: 10.4103/2152-7806.134731. eCollection 2014. Review. PubMed PMID: 25024897;
PubMed Central PMCID: PMC4093745.
5: Mahendrakar K, Venkategowda PM, Rao SM, Mutkule DP. Glyphosate surfactant
herbicide poisoning and management. Indian J Crit Care Med. 2014
May;18(5):328-30. doi: 10.4103/0972-5229.132508. PubMed PMID: 24914265; PubMed
Central PMCID: PMC4047698.
6: Schinasi L, Leon ME. Non-Hodgkin lymphoma and occupational exposure to
agricultural pesticide chemical groups and active ingredients: a systematic
review and meta-analysis. Int J Environ Res Public Health. 2014 Apr
23;11(4):4449-527. doi: 10.3390/ijerph110404449. Review. PubMed PMID: 24762670;
PubMed Central PMCID: PMC4025008.
7: Mesnage R, Defarge N, Spiroux de Vendômois J, Séralini GE. Major pesticides
are more toxic to human cells than their declared active principles. Biomed Res
Int. 2014;2014:179691. doi: 10.1155/2014/179691. Epub 2014 Feb 26. PubMed PMID:
24719846; PubMed Central PMCID: PMC3955666.
8: Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue
and gluten intolerance. Interdiscip Toxicol. 2013 Dec;6(4):159-84. doi:
10.2478/intox-2013-0026. Review. PubMed PMID: 24678255; PubMed Central PMCID:
PMC3945755.
9: Chaufan G, Coalova I, Ríos de Molina Mdel C. Glyphosate commercial formulation
causes cytotoxicity, oxidative effects, and apoptosis on human cells: differences
with its active ingredient. Int J Toxicol. 2014 Jan-Feb;33(1):29-38. doi:
10.1177/1091581813517906. Epub 2014 Jan 16. PubMed PMID: 24434723.
10: Garlich FM, Goldman M, Pepe J, Nelson LS, Allan MJ, Goldstein DA, Goldfarb
DS, Hoffman RS. Hemodialysis clearance of glyphosate following a life-threatening
ingestion of glyphosate-surfactant herbicide. Clin Toxicol (Phila). 2014
Jan;52(1):66-71. doi: 10.3109/15563650.2013.870344. PubMed PMID: 24400933.
11: Krüger M, Shehata AA, Schrödl W, Rodloff A. Glyphosate suppresses the
antagonistic effect of Enterococcus spp. on Clostridium botulinum. Anaerobe. 2013
Apr;20:74-8. doi: 10.1016/j.anaerobe.2013.01.005. Epub 2013 Feb 6. PubMed PMID:
23396248.
12: Shehata AA, Schrödl W, Aldin AA, Hafez HM, Krüger M. The effect of glyphosate
on potential pathogens and beneficial members of poultry microbiota in vitro.
Curr Microbiol. 2013 Apr;66(4):350-8. doi: 10.1007/s00284-012-0277-2. Epub 2012
Dec 9. PubMed PMID: 23224412.

The Symbiont Factor is now a paperback, available on Amazon!

After a year and a half of having a second job as a new author, my first book is finally available in print! A comprehensive, thoroughly referenced guide to how our gut bacteria influence physical and mental health: The Symbiont Factor is now available on Amazon as a paperback! If you ever wondered if and why probiotics are healthy you should read this book. Please share with your contacts 🙂     http://tinyurl.com/pe2g4xt

A Good Guide to Breathing Exercises to Help your Gut Bacteria

In The Symbiont Factor (http://amzn.to/1jz3kPt), I explain that one of the most important variables that we can influence to improve our gut bacteria is autonomic tone. When we are stressed, we become sympathetic (think “fight or flight”) dominant and this functional pattern inhibits digestion and gut mobility. This inhibition is also very harmful to beneficial gut bacteria! So, what can be done short-term to reverse this pattern? Breathing exercises. When under stress, most people suppress their breathing, contributing to sympathetic autonomic tone. When you take deep breaths instead, it stimulates your parasympathetic system, and this is the system that makes your gut function improve. Gut bacteria thrive in this functional pattern!  Now the only question is how to learn to improve breathing dynamics and build a “better-breathing” habit. One resource that I found tremendously helpful in learning this came from one of the sports I participate in: Freediving.  There is a great book called Breatheology, written by Stig Severinsen, which deals with specifically that: how to improve our breathing. You can find the book here: http://amzn.to/1nQYwAr. FYI-as I’m in Arkansas, I earn nothing from that link/referral; I’m listing it purely because I think it is that good! Of course, it makes a nice complement to the book I wrote…

How Women can Reduce their Susceptibility to Sexually Transmitted Diseases, Including HIV Infection!

Did you know that a woman’s microbiome, her resident population of symbiont bacteria, plays a critical role in her susceptibility to sexually transmitted diseases, including HIV infection? How could bacteria protect a person from disease? If you would like answers to questions like this one, check out my newly released book, The Symbiont Factor. Find it here: http://amzn.to/1jz3kPt

The Symbiont Factor is now Published!! Live on Amazon!

Today is the day I finally got to click on the “submit” button and make my book available on Amazon. After a year of hard work writing and making edit corrections, it’s done!  A print copy will be available soon-for now only the e-book version is available.

Here is the link to the book on Amazon: http://amzn.to/1jz3kPt