Brain Fog and Gluten

Wheat gluten, the protein found in wheat, rye, and barley, has long been recognized as a common trigger for celiac disease, an autoimmune disorder that damages the small intestine. However, recent research has also suggested that wheat gluten may be a potential trigger for brain fog, a symptom characterized by difficulty with concentration, memory, and cognitive function. Additionally, some individuals may experience symptoms of brain fog and other health issues as a result of non-celiac gluten sensitivity, a condition that is distinct from celiac disease but still involves an adverse reaction to wheat gluten.

One possible mechanism by which wheat gluten may cause brain fog is through a process called molecular mimicry. Molecular mimicry occurs when the immune system mistakes a protein in a foreign substance, such as wheat gluten, for a protein in the body’s own tissues. The immune system then mounts an immune response against the foreign protein, resulting in an autoimmune reaction that can damage the body’s own tissues.

In the case of wheat gluten and brain fog, it is thought that the immune system may mistake proteins in wheat gluten, such as gliadins and glutenins, for proteins in the brain and central nervous system. This mistaken immune response can lead to inflammation and damage in the brain and nervous system, resulting in symptoms of brain fog.

Another possible mechanism by which wheat gluten may trigger brain fog is through the production of immunoglobulin G (IgG) antibodies. IgG antibodies are produced by the immune system as a response to foreign substances, including proteins in wheat gluten. The presence of IgG antibodies to wheat gluten has been linked to a variety of neurological symptoms, including brain fog, headaches, and fatigue.

It is thought that the production of IgG antibodies to wheat gluten may be a result of an enzyme called transglutaminase. Transglutaminase is an enzyme found in the small intestine that helps to break down wheat gluten. However, in individuals with celiac disease or non-celiac gluten sensitivity, transglutaminase may not function properly, leading to the production of IgG antibodies to wheat gluten.

If you are experiencing brain fog and are interested in testing for celiac disease, non-celiac gluten sensitivity, or leaky gut, you can order a fingerprick blood test from Vibrant Wellness Labs through this link: This simple and convenient test can provide valuable insights into your health and help you determine the best course of action to address any underlying issues.


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