Synergy! what is it? How probiotics and gut bacteria influence sirtuins, oxidative stress, and inflammation!

400 x 400 tsf gbI’ve recently started implementing a new product line at my clinic, one that I feel does a superior job of activating the body’s ability to combat inflammation and oxidative stress, while improving the Sirtuin system and healing mitochondria.

But first…what does that even mean?

Inflammation: when the immune system reacts to the body (but not as much as autoimmunity) and causes damage in the process.

Oxidative stress: when the body’s cells attempt to burn up more fuel than available, or are functioning inefficiently, due to harmful metabolic byproducts such as free radicals or inflammation.

Sirtuin system: Silent Information Regulator genes. This gene system regulates many body functions, and is implicated in the aging process as well as the regulation of many vital functions.

Mitochondria: these are the tiny organelles that live inside all of our cells and provide metabolic fuel to essentially fuel life.

What do these four systems have in common? They are vital to life and are part of the aging and disease process.

There is a synergy involved when all of these systems are aided, because they do not work in isolation. For example, improving mitochondria will reduce oxidative stress, as it improves the cell’s ability to metabolize fuel.

But wait! there’s more! Gut bacteria (you knew I was getting to that, right?) also improve these systems. Probiotics have been shown to improve the sirtuin system, reduce inflammation and oxidative stress, and improve mitochondrial health and function. 

Isn’t it truly amazing that the human body has so many ways to heal, and that we have access to amazing products that help those processes?

Please let me know your thoughts!

Want to know more about how to experience this synergy?? Please message me on FB ( or send me an email (

Also, if you haven’t yet, please be sure to get my book about gut bacteria, The Symbiont Factor! (

Stay well!

Richard Matthews DC DACNB



Lactobacillus plantarum reduces oxidative stress and upregulates Nrf2:

Lactobacillus upregulates NRF-2:

Probiotics reduce inflammation and oxidative stress:

Lactobacillus acidophilus aids Sir2:

Lactobacillus casei activates Sir1 and improves glycemic response in T2DM:

Bifidobacterium longum, Lactobacillus acidophilus activate Sir2 to reduce oxidative stress:


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.