How Lyme bacteria uses your immune system against you, and what to do about it!

tick_deer

Lyme disease is caused by a very versatile bacteria of the genus Borrelia. The most common species is Borrelia burgdorferi, but there are several others such as B garinii and B miyamotoi, which also cause relapsing fevers almost identical to Lyme Disease. Borrelia is able to use your immune system to help it infect you! Read on to find out how, and what you can do about it.

Our immune system has several divisions, just like our military has Air Force, Navy, Marines, Army, Coast Guard as its parts. Each serves a purpose in defense. In your immune system, a type of T-cell produces something called Gamma Interferon. This is an inflammatory molecule, something called a Cytokine. Normally, it’s produced to fight off viral or bacterial infections. Another part of your immune system, the complement system, produces antibodies that are keyed, just like a key to a lock, to the outer protein of an invading bacteria. This antibody response guides the immune system in what to kill by tagging it in this manner. It’s actually waaay more complicated, but this is essentially how it works.

Borrelia bacteria have the ability to produce (“express”) different proteins for outer shells. It has genetic coding (“vlsE cassette”) for many combinations of outer proteins. But, it can’t express those proteins without help. Researchers have proven that to succeed at infection, the bacteria requires the host to produce gamma interferon, which it uses to activate a different gene sequence and change its outer protein coating. Yes, that’s a bit like if the bank robber heard the APB and asked a passing police officer to help him change his trench coat and hat so that he didn’t match the description in the APB. Pretty strange, right? This has been extensively researched and proven as one of the critical mechanisms the bacteria uses to cause Lyme disease.

With that in mind, what would happen if you reduced the production of gamma interferon? Well, that has been looked at, and if this is done the bacteria can’t succeed at infecting because the immune system will kill it before it can hide. So, reducing inflammation, and specifically gamma interferon in addition to nf-kappa B, IL-17, and TNF alpha, helps the immune system. Those other cytokines I mentioned? they’re responsible for allowing brain infection and joint infection, as well as making you hurt all over.

Do we have anything that can inhibit these cytokines without harming the patient? yes, in fact, we do. Two critical ingredients, and some strategies:

  1. Curcumin inhibits all of these inflammatory cytokines, particularly gamma interferon.
  2. Andrographis, an herb, also is anti-inflammatory and inhibits cytokine production. It has been shown to inhibit gamma interferon
  3. CBD oil helps reduce inflammation as well
  4. Healthy and diverse gut bacteria help your immune system to produce IL-10 and IL-4, which reduce T-cell production of inflammatory cytokines.
  5. Avoiding things that cause inflammation, like those foods you’re sensitized to or excess sweets or deep fried foods, also helps reduce cytokine production

These four steps are critical to either helping antibiotics kill off a Lyme infection, or keeping it gone (because it forms biofilms, it doesn’t get 100% killed) or fighting it off when it comes back and antibiotics aren’t an option.

For more information about the best Lyme testing I’ve found, visit my Lyme testing page at LymeTest4u.com.

For curcumin, this is my current best recommendation: https://www.neurodoc4u.com/product-page/c3-curcumin-4-oz

Andrographis capsules: https://www.neurodoc4u.com/product-page/andrographis-paniculata-capsules

CBD oil: This is the 1000mg “good stuff”! https://www.neurodoc4u.com/product-page/cbd-oil-1000mg

If you’re interested in improving your gut bacteria, the process starts with seeing what’s there to work with. This is done through a stool sample you send to a lab. The one I recommend is uBiome. You can go to ubiome.com and order a Time Lapse kit. Use the discount code SYMBIONTFACTOR and you’ll save an additional 15%!

References:

Andrographolide affects Th1/Th2/Th17 responses of peripheral blood mononuclear cells from ulcerative colitis patients.

Zhu Q, Zheng P, Zhou J, Chen X, Feng Y, Wang W, Zhou F, He Q.

Mol Med Rep. 2018 Jul;18(1):622-626. doi: 10.3892/mmr.2018.8992. Epub 2018 May 8.

Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon.

Couch DG, Tasker C, Theophilidou E, Lund JN, O’Sullivan SE.

Clin Sci (Lond). 2017 Oct 25;131(21):2611-2626. doi: 10.1042/CS20171288. Print 2017 Nov 1.

Borrelia burgdorferi induces a type I interferon response during early stages of disseminated infection in mice.

Petzke MM, Iyer R, Love AC, Spieler Z, Brooks A, Schwartz I.

BMC Microbiol. 2016 Mar 8;16:29. doi: 10.1186/s12866-016-0644-4.

Dietary Non-digestible Polysaccharides Ameliorate Intestinal Epithelial Barrier Dysfunction in IL-10 Knockout Mice.

Wang H, Shi P, Zuo L, Dong J, Zhao J, Liu Q, Zhu W.

J Crohns Colitis. 2016 Sep;10(9):1076-86. doi: 10.1093/ecco-jcc/jjw065. Epub 2016 Mar 3.

Detection of IFN-γ Secretion by T Cells Collected Before and After Successful Treatment of Early Lyme Disease.

Callister SM, Jobe DA, Stuparic-Stancic A, Miyamasu M, Boyle J, Dattwyler RJ, Arnaboldi PM.

Clin Infect Dis. 2016 May 15;62(10):1235-1241. doi: 10.1093/cid/ciw112. Epub 2016 Mar 1.

Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase.

Fuertig R, Azzinnari D, Bergamini G, Cathomas F, Sigrist H, Seifritz E, Vavassori S, Luippold A, Hengerer B, Ceci A, Pryce CR.

Brain Behav Immun. 2016 May;54:59-72. doi: 10.1016/j.bbi.2015.12.020. Epub 2015 Dec 24.

Andrographolide Ameliorates Abdominal Aortic Aneurysm Progression by Inhibiting Inflammatory Cell Infiltration through Downregulation of Cytokine and Integrin Expression.

Ren J, Liu Z, Wang Q, Giles J, Greenberg J, Sheibani N, Kent KC, Liu B.

J Pharmacol Exp Ther. 2016 Jan;356(1):137-47. doi: 10.1124/jpet.115.227934. Epub 2015 Oct 19.

Curcuminoids and ω-3 fatty acids with anti-oxidants potentiate cytotoxicity of natural killer cells against pancreatic ductal adenocarcinoma cells and inhibit interferon γ production.

Halder RC, Almasi A, Sagong B, Leung J, Jewett A, Fiala M.

Front Physiol. 2015 May 22;6:129. doi: 10.3389/fphys.2015.00129. eCollection 2015.

Curcumin and omega-3 fatty acids enhance NK cell-induced apoptosis of pancreatic cancer cells but curcumin inhibits interferon-γ production: benefits of omega-3 with curcumin against cancer.

Fiala M.

Molecules. 2015 Feb 12;20(2):3020-6. doi: 10.3390/molecules20023020. Review.

Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease.

Jiang W, Wu N, Wang X, Chi Y, Zhang Y, Qiu X, Hu Y, Li J, Liu Y.

Sci Rep. 2015 Feb 3;5:8096. doi: 10.1038/srep08096.

Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production.

Ma Y, Bramwell KK, Lochhead RB, Paquette JK, Zachary JF, Weis JH, Teuscher C, Weis JJ.

J Immunol. 2014 Dec 15;193(12):6050-60. doi: 10.4049/jimmunol.1401746. Epub 2014 Nov 5.

Induction of type I and type III interferons by Borrelia burgdorferi correlates with pathogenesis and requires linear plasmid 36.

Krupna-Gaylord MA, Liveris D, Love AC, Wormser GP, Schwartz I, Petzke MM.

PLoS One. 2014 Jun 19;9(6):e100174. doi: 10.1371/journal.pone.0100174. eCollection 2014.

Borrelia burgdorferi RNA induces type I and III interferons via Toll-like receptor 7 and contributes to production of NF-κB-dependent cytokines.

Love AC, Schwartz I, Petzke MM.

Infect Immun. 2014 Jun;82(6):2405-16. doi: 10.1128/IAI.01617-14. Epub 2014 Mar 24.

Diagnostic value of cytokines and chemokines in lyme neuroborreliosis.

Cerar T, Ogrinc K, Lotric-Furlan S, Kobal J, Levicnik-Stezinar S, Strle F, Ruzić-Sabljic E.

Clin Vaccine Immunol. 2013 Oct;20(10):1578-84. doi: 10.1128/CVI.00353-13. Epub 2013 Aug 14.

Orchestration of inflammation and adaptive immunity in Borrelia burgdorferi-induced arthritis by neutrophil-activating protein A.

Codolo G, Bossi F, Durigutto P, Bella CD, Fischetti F, Amedei A, Tedesco F, D’Elios S, Cimmino M, Micheletti A, Cassatella MA, D’Elios MM, de Bernard M.

Arthritis Rheum. 2013 May;65(5):1232-42. doi: 10.1002/art.37875.

Early-life gut bacteria associate with IL-4-, IL-10- and IFN-γ production at two years of age.

Johansson MA, Saghafian-Hedengren S, Haileselassie Y, Roos S, Troye-Blomberg M, Nilsson C, Sverremark-Ekström E.

PLoS One. 2012;7(11):e49315. doi: 10.1371/journal.pone.0049315. Epub 2012 Nov 20.

The psychoimmunology of lyme/tick-borne diseases and its association with neuropsychiatric symptoms.

Bransfield RC.

Open Neurol J. 2012;6:88-93. doi: 10.2174/1874205X01206010088. Epub 2012 Oct 5.

Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue.

Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ.

J Immunol. 2012 Sep 1;189(5):2488-501. doi: 10.4049/jimmunol.1201095. Epub 2012 Jul 30.

Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis.

Strle K, Shin JJ, Glickstein LJ, Steere AC.

Arthritis Rheum. 2012 May;64(5):1497-507. doi: 10.1002/art.34383.

Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface.

Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8743-8. doi: 10.1073/pnas.1019574108. Epub 2011 May 9.

Mechanisms controlling Th17 cytokine expression and host defense.

McAleer JP, Kolls JK.

J Leukoc Biol. 2011 Aug;90(2):263-70. doi: 10.1189/jlb.0211099. Epub 2011 Apr 12. Review.

A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice.

Miller JC, Ma Y, Bian J, Sheehan KC, Zachary JF, Weis JH, Schreiber RD, Weis JJ.

J Immunol. 2008 Dec 15;181(12):8492-503.

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients.

Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottière HM, Doré J, Marteau P, Seksik P, Langella P.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6. doi: 10.1073/pnas.0804812105. Epub 2008 Oct 20.

[Concentrations of pro-inflammatory cytokines IFN-gamma, IL-6, IL-12 and IL-15 in serum and cerebrospinal fluid in patients with neuroborreliosis undergoing antibiotic treatment].

Pancewicz SA, Kondrusik M, Zajkowska J, Grygorczuk S.

Pol Merkur Lekarski. 2007 Apr;22(130):275-9. Polish.

IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation.

Dame TM, Orenzoff BL, Palmer LE, Furie MB.

J Immunol. 2007 Jan 15;178(2):1172-9.

Lyme arthritis synovial gammadelta T cells instruct dendritic cells via fas ligand.

Collins C, Wolfe J, Roessner K, Shi C, Sigal LH, Budd RC.

J Immunol. 2005 Nov 1;175(9):5656-65.

Up-regulation of Borrelia-specific IL-4- and IFN-gamma-secreting cells in cerebrospinal fluid from children with Lyme neuroborreliosis.

Widhe M, Skogman BH, Jarefors S, Eknefelt M, Eneström G, Nordwall M, Ekerfelt C, Croner S, Bergström S, Forsberg P, Ernerudh J.

Int Immunol. 2005 Oct;17(10):1283-91.

Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis.

Burgos RA, Seguel K, Perez M, Meneses A, Ortega M, Guarda MI, Loaiza A, Hancke JL.

Planta Med. 2005 May;71(5):429-34.

Borrelia-specific interferon-gamma and interleukin-4 secretion in cerebrospinal fluid and blood during Lyme borreliosis in humans: association with clinical outcome.

Widhe M, Jarefors S, Ekerfelt C, Vrethem M, Bergstrom S, Forsberg P, Ernerudh J.

J Infect Dis. 2004 May 15;189(10):1881-91. Epub 2004 Apr 26.

Neutralization of gamma interferon augments borreliacidal antibody production and severe destructive Lyme arthritis in C3H/HeJ mice.

Munson EL, DeCoster DJ, Nardelli DT, England DM, Callister SM, Schell RF.

Clin Diagn Lab Immunol. 2004 Jan;11(1):35-41.

Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans.

Glickstein L, Moore B, Bledsoe T, Damle N, Sikand V, Steere AC.

Infect Immun. 2003 Oct;71(10):6051-3.

Gamma interferon inhibits production of Anti-OspA borreliacidal antibody in vitro.

Munson EL, Du Chateau BK, Jensen JR, Callister SM, DeCoster DJ, Schell RF.

Clin Diagn Lab Immunol. 2002 Sep;9(5):1095-101.

Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination.

Anguita J, Thomas V, Samanta S, Persinski R, Hernanz C, Barthold SW, Fikrig E.

J Immunol. 2001 Sep 15;167(6):3383-90.

Salivary gland extract from Ixodes ricinus ticks inhibits production of interferon-gamma by the upregulation of interleukin-10.

Kopecký J, Kuthejlová M, Pechová J.

Parasite Immunol. 1999 Jul;21(7):351-6.

Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection.

Pohl-Koppe A, Balashov KE, Steere AC, Logigian EL, Hafler DA.

J Immunol. 1998 Feb 15;160(4):1804-10.

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Dr. Richard Matthews

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