Monthly Archives: March 2016

Stress, Microbiome, Inflammation and the Pancreas & Liver

flow chart stress intestinal function inflammation

Sometimes things happen that seem to come out of nowhere. It happens to all of us, usually when we least expect it because we are busy taking care of others or life in general. So here’s a scenario: Imagine that one day your blood sugar suddenly skyrockets and your Medical physician informs you that your liver and pancreas are not functioning properly. What could cause this? Well, many things could, but the one thing in common is inflammation. If the pancreas is inflamed, the Islets of Langerhans sometimes stop producing insulin and blood sugar doesn’t get stored, so it jumps up. If the inflammation is early in life, the immune system may go to the point of forming antibodies to the Islets, destroying them and causing Type 1 diabetes. If the body becomes inflamed later in life, cells may not respond to insulin anymore, causing Type 2 diabetes. But if the pancreas is inflamed, it doesn’t work properly. The liver can be implicated too, as it stores extra energy (glucose) reserves for when you need them. Liver inflammation can also cause diabetes. While these changes are all known to occur in people that are obese and have an unhealthy diet, how is it possible for it to happen this quickly, and in someone who isn’t obese? The answer lies in the fact that the immune system is mostly controlled by our gut bacteria and GALT, or gut-associated lymphoid tissue, dendritic nerve endings, and other points of information exchange between the microbiome and the host immune system.

Research has shown that exposure to short-term social/emotional stress causes alteration of the gut microbiome. This altered microbiome in turn does not control the immune system approriately, resulting in increased systemic inflammation (which can make the social stress worse, as both the inflammation and the altered microbiome affect brain function and mood). See the illustration above, which is from my book The Symbiont Factor.

Another factor that can alter the microbiome and trigger widespread inflammation is short term dietary change, to a less beneficial diet. In research terminology, a diet that causes microbiome demise, inflammation and disease is called a Western Diet. It is used to produce a sick lab animal to study, and mimics what the average American consumer eats every day.

Sleep is absolutely necessary for a healthy microbiome, and disruptions of our circadian rhythms and sleep cycles has been shown to disrupt our microbiome and cause inflammation.

Exposure to air affects our microbiome too! Air is actually replete will huge numbers of human skin cells and bacteria from other people in the vicinity. The longer we are in a space with other people, the more we inhale parts of their microbiome combined with the microbiome of the space. These organisms then influence our own microbiome, so if the exposure was to unhealthy microbiomes, the result can be…inflammation once more.

Sometimes the scenario can revive imbalances and infections we’ve had before, such as chronic viral infections (shingles, for example, or herpes) or chronic bacterial infections such as Lyme disease-where the organism was in a dormant state due to good immune function-waiting for an opportunity.

Ok, so…can we picture a scenario where all of the above are combined? Stress, bad food, interrupted sleep with no real dark/light cycles, and lots of sick people/bad bacteria? Bingo-it’s the place where we send people to get well: a hospital.

What should we do to recover from this systemic inflammation?

  1. Regular sleep, hitting the bed and waking same time every day, preferably in a multiple of 90 minutes. So, 6 hours, 7.5 hours, 9 hours so that we don’t interrupt a sleep cycle. No lights, no devices at night. No bright little blue “charging” LEDs.
  2. Healthy food, and preferably some of it fermented. There is a great fermented oatmeal recipe earlier on this blog, and many areas have private individuals making fantastic fermented vegetables. Here in coastal Maine, “A Stone’s Throw to Health” is one such business, with handcrafted ferments by Sheila Perloff-Eddison.
  3. Avoid deep fried food, hydrogenated fats, sweets, gluten. Even if you’re not gluten sensitive, eating it when you’re inflamed raises the odds of you becoming gluten sensitive. No fast food. Real meat, vegetable, greens, fruit.
  4. Probiotic Bifidobacteria, in double the normal doses. Add prebiotic inulin, pectin, FOS, GOS supplements to help feed the newly introduced organisms.
  5. Curcumin is hugely effective for reducing inflammation, improving insulin sensitivity, healing liver and pancreas. Not turmeric, which is 5% curcumin, but 95% curcumin-the real stuff. I take 6-8 capsules a day, minimum, if I’m injured or inflamed. It works better than drugs-check out the Ghosh study in the bibliography below.
  6. Some other products, such as jerusalem artichokes/sunchokes, jicama, artichokes, asparagus, pomegranate, rhubarb, ginger have been shown to have fantastic prebiotic and anti-inflammatory benefits.
  7. Make a point of, several times per day, praying or meditating on peaceful/optimistic and loving thoughts while breathing deeply. The physiologic effects improve autonomic tone and gut function, helping to recolonize healthy bacteria while healing gut membranes.

 

Sources:

Fermented Vegetables: http://www.astonesthrowtohealth.com/

Curcumin: http://progressivelabs.com/product.php?productid=17110&cat=0&page=1

Inulin: http://www.amazon.com/Prebiotin-Prebiotic-Fiber-8-5-Powder/dp/B001RVFSFS/ref=sr_1_2_a_it?ie=UTF8&qid=1459361720&sr=8-2&keywords=prebiotic

For more info: http://www.amazon.com/Symbiont-Factor-Microbiome-Redefines-Humanity/dp/1500553948/

Fermented oatmeal recipe: https://thesymbiontfactorblog.com/2016/01/26/super-synbiotic-breakfast-improved/

 

Bibliography:

Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota.

Neyrinck AM, Etxeberria U, Taminiau B, Daube G, Van Hul M, Everard A, Cani PD, Bindels LB, Delzenne NM.

Mol Nutr Food Res. 2016 Mar 18. doi: 10.1002/mnfr.201500899. [Epub ahead of print]

PMID:26990039

Combination with Red ginseng and Polygoni Multiflori ameliorates highfructose diet induced metabolic syndrome.

Kho MC, Lee YJ, Park JH, Cha JD, Choi KM, Kang DG, Lee HS.

BMC Complement Altern Med. 2016 Mar 9;16(1):98. doi: 10.1186/s12906-016-1063-7.

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Chronic Psychological Stress Disrupted the Composition of the Murine Colonic Microbiota and Accelerated a Murine Model of Inflammatory Bowel Disease.

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PLoS One. 2016 Mar 7;11(3):e0150559. doi: 10.1371/journal.pone.0150559. eCollection 2016.

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Early Alterations in Glycemic Control and Pancreatic Endocrine Function in Nondiabetic Patients With Chronic Pancreatitis.

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Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.

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Pollution and Gut Bacteria: A Different Take

mine-waste-leak

Our planet is becoming increasingly toxic, as we add more chemicals to its  air, rivers, lakes and ocean every day. While laws designed to curb pollution have probably helped, they don’t prevent things like massive oil spills or the release of antibiotic or hormone residues from farm animals and humans. You see, all of those pharmaceutical products used to produce a steak from an overcrowded, stressed and diseased animal, almost all of those substances get passed by the animal, and run downstream-eventually to lakes and oceans. Toxic materials such as arsenic and mercury are common. The yellow water in the image above is from a mine leak in Colorado (image from The Durango Herald). The water debacle in Flint, Michigan is just one example of how toxins are present. With those admittedly grim thoughts in mind, what are the most adaptable organisms on the planet? Yes, bacteria. With the ability to share DNA in horizontal transfer and a gene pool replete with ways to break down poisons, bacteria have been at the toxin-vs-detoxify game for over a billion years. What if the bacteria that live inside our bodies could help us to detoxify? Perhaps a different way to ask the same question would be to ask why, given a somewhat consistent toxin exposure in a given neighborhood or community, do some people develop toxicity while others do not? As it turns out, some of our beneficial symbionts (Lactobacillus) can do exactly that. A study found that these bacteria can break down pesticides, and reduced the accumulation of arsenic and mercury in pregnant women and children. That should be pretty good news, right? It is if you make efforts to keep these organisms present. They are often reduced or absent due to antibiotic use/abuse and poor nutritional choices. Ironically, the poor people that are often exposed to these toxins also tend not to buy organic produce or have the educational background required to make the right choices. Instead, they are the victims of our capitalistic dark side, believing that it’s normal to eat McDonalds or Wendy’s on a regular basis and consume Pepsi or Coke instead of water. Elective C-section births are very common, and many new mothers are not taught the benefits or techniques of breastfeeding. The combination of c-section and bottle feeding robs a newborn of the microbiome needed for optimal brain and immune system development. Now we can also say it leaves this child more vulnerable to the effects of pesticides and toxins. This affects all of us in one way or another, and it is simply wrong on many levels to allow it to continue.

One long-term result of the intergenerational demise of the microbiome is that while our planet is accumulating toxins and poisons, our microbiome which could help us to detoxify those substances is on the way down. As the “modern” world infects virginal areas and their indigenous people, bringing them antibiotics and Coca-Cola, the core ancestral microbiome becomes an endangered entity.

It is vitally important that more people understand how the microbiome is necessary for so many aspects of life. It is also important to put in place limitations on drug and chemical releases into the environment, as the current system is not a bucket but a sieve, giving the illusion of containment from a distance but constantly leaking in many directions. Even our nuclear power plants in the USA have joined Fukushima in leaking radioactive waste into the ocean (Indian Point in NY has been leaking).

If mankind does not change the trajectory that our species has been on for some time, it is only a matter of time before our health is so fragile and our planet is so toxic that life will no longer be possible the way it is now. Even if that were to take 500 years, it is still the path we’re on. Perhaps, when the Bible stated that “the meek shall inherit the earth,” it was really a microbial prophecy, as bacteria were the first organisms here and will likely be the last. It’s probably a good time to make sure that your microbiome is fully operational, as it helps you cope with toxic exposures. Perhaps it’s time to coin the term “microbiome survivalist?”

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