What are the causes of dysbiosis and resultant dysfunction/disease? One cause that seems to be greatly underestimated may be simply our mood! Human beings, having been gifted with large frontal lobes, are capable of experiencing and expressing a variety of moods. Our bodies respond to these moods with different functional states, some of which have been categorized. These are “fight or flight (or sometimes, fight/flee/fortify)” or “wine and dine”. There are many more physiological functional arousal states that we could elaborate on, but many of them could make this blog post NSFW. We’ll just assume that your imagination can fill in the blanks with how the body responds to the mind! With the brain-gut connection in mind, and being also cognizant that it’s a two-way street since the gut influences the brain, what would be the influence of stress? One that comes to mind right away is a reduction in gut motility. This changes the environment in which the microbiome exists, and will change the demographics of the microorganisms. What about the effects of peristalsis on the small intestine? If there is less peristalsis, wouldn’t it make it easier for colonic organisms to migrate to the small intestine? If transit times increase, different stages of food digestion could release different nutrients, feeding different organisms. When do we cross from fermentative to putrefactive dominance? Using one of the concepts in The Symbiont Factor, this two-way function of gut/brain/gut axis can cause a positive feedback loop. If gut organisms that flourish during emotional stress can also alter neurotransmitter function at the brain, wouldn’t that predispose the brain to perceive stress following stressful events? What if that is why sometimes after a stressful day we just have more stress, no matter what happens? It is as if our very perception of our environment is vulnerable to plasticity. If this is allowed to happen without our conscious intervention (things like deciding to meditate or do some yoga even though you’re angry) the combination of evoked brain plasticity with gut symbiont evolution could be what makes it hard to shake off stress! Ironically, this same plasticity is probably an evolutionary advantage, allowing genetic selection of the microbiome on an ongoing real-time basis to adapt to circumstances. The problem is that our modern circumstances provide constant chemical and emotional pressure to this system, resulting in “learned dysfunction” of both the gut and the brain! This highlights the importance of “mental housekeeping” and lifestyle choices in determining our “perceptual future”. If you don’t want the world to seem as stressful, start taking care of mind, body, and symbiont health!