Autism, Gut Bacteria and the HPA Axis-What is the connection?

The HPA axis is not a part of the body that is often discussed. It is a functional “axis” that is used to describe the relationship between three parts of the body: the Hypothalamus, the Pituitary gland, and the Adrenal glands. All three of these organs have critical functions with far-reaching implications for physical and mental health. Many psychiatric drugs have been found to affect the HPA axis, resulting in the therapeutic benefit of the drug. Imbalances in HPA function have been implicated in a wide array of neuropsychiatric conditions including in autism. The gut microbiome, gut bacteria, exert control over the development and function of the endocrine hormone system, in particular the HPA axis. Why does this matter? Because imbalances in gut bacteria can therefore result in imbalances in HPA axis development in early life-and this imbalance has the potential to make the person develop autism (as well as other problems in different individuals). It is important because the gut bacteria are so vulnerable to birth practices (c-section vs. natural), antibiotic use, antibiotics in food, pesticides, herbicides such as RoundUp, and even stress levels perceived by the individual. Higher stress is harmful to the gut bacteria through alterations of the digestive functions, secondary to autonomic nervous system imbalance (more sympathetic, or “fight-or-flight”, function).  Many of these are factors under our influence if not control! Gut bacterial populations are one of the most variable factors in human health, and yet one of the most neglected. My work on The Symbiont Factor is my contribution to spreading knowledge about the gut microbiome, so that more people can take control of their health and more conditions like autism can hopefully be prevented or successfully treated. The book is being configured/edited/reconfigured/formatted so that it works well on all Kindle download platforms, a task that is keeping me quite busy the last two weeks! Almost there, almost there…It will be so exciting when it is finally published! The book will also be available as a print format following its release as an e-book. Until then, stay tuned in and take care of your gut bacteria!

References:

http://www.colorado.edu/news/releases/2013/12/19/research-linking-autism-symptoms-gut-microbes-called-%E2%80%98groundbreaking%E2%80%99-cu

http://www.ageofautism.com/2014/05/the-microbiome-could-it-be-the-epicenter-of-autism.html

http://www.jwatch.org/na33305/2014/01/28/more-evidence-links-gut-microbiome-autism

http://www.ncbi.nlm.nih.gov/pubmed/24882156

http://www.ncbi.nlm.nih.gov/pubmed/24715565

http://www.ncbi.nlm.nih.gov/pubmed/24892638

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985034/

http://www.ncbi.nlm.nih.gov/pubmed/24636517

And, best of all, a slide show from one of the head researchers in the field, Ted Dinan: http://www.genome.gov/Multimedia/Slides/HumanMicrobiomeScience2013/33_Dinan.pdf

 

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